Fri Jan 21 2022

28 articles - From Saturday Jan 15 2022 to Friday Jan 21 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Studies

RCT, clinical trials, retrospective studies, etc…

Ann Rheum Dis

Accounting for missing data caused by drug cessation in observational comparative effectiveness research: a simulation study.

Only multiple imputation and IPW2, which considered both confounding and treatment cessation reasons, produced accurate comparative effectiveness estimates.

Pubmed   Journal   ReadQx 

Additional heterologous versus homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination: a randomised controlled trial.

This enhanced humoral and/or cellular immune response supports an additional booster vaccination in non-seroconverted patients irrespective of a heterologous or homologous vaccination regimen.

Pubmed   Journal   ReadQx 

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.

The MHC-peptide-TCR interactions elucidated in our study provide new molecular insights into recognition of a post-translationally modified RA T-cell determinant with a known dominant role in arthritogenic and tolerogenic responses in murine Col2-induced arthritis.

Pubmed   Journal   ReadQx 

Tofacitinib and risk of cardiovascular outcomes: results from the Safety of TofAcitinib in Routine care patients with Rheumatoid Arthritis (STAR-RA) study.

We did not find evidence for an increased risk of cardiovascular outcomes with tofacitinib in patients with RA treated in the real-world setting; however, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.

Pubmed   Journal   ReadQx 

Arthritis Care Res (Hoboken)

Association of Healthy Lifestyle Behaviors and the Risk of Developing Rheumatoid Arthritis among Women.

In this prospective cohort, healthier lifestyle was associated with lower RA risk. A substantial proportion of RA may be preventable by healthy lifestyle.

Pubmed   Journal   ReadQx 

Clinical Academic Rheumatology: A Boon for Health Systems.

For every $1 generated though office visits by five practicing academic rheumatologists at our institution $12.14 were generated through downstream revenue, which when adjusted for inflation shows stability in the value generated by academic rheumatologists ($10.02 vs $9.37).

Pubmed   Journal   ReadQx 

Dosing Variation at Initiation of Adalimumab and Etanercept is not Associated with Clinical Outcomes in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry study.

This study was not able to confirm our hypothesis that increased dosing of TNF inhibitors results in improved treatment outcomes. Although adjustment was performed for risk factors of impaired treatment response, residual confounding by indication likely explains the negative associations found in this study.

Pubmed   Journal   ReadQx 

Incidence and prevalence of knee osteoarthritis using codified and narrative data from electronic health records: a population-based study.

Our study of a Dutch primary care database showed that current incidence and prevalence estimates based on codified data alone from electronic health records are underestimated. Narrative data can be incorporated in addition to codified data to identify knee OA patients more accurately.

Pubmed   Journal   ReadQx 

Patient Perceptions and Preferences Regarding Telemedicine for Rheumatologic Care during the COVID-19 Pandemic.

During the pandemic, patients with autoimmune rheumatic diseases frequently had telemedicine visits, the majority via video, and were satisfied with these visits. These results suggest that because patients prefer telemedicine for certain visit reasons, maximizing effective use of telemedicine will require personalized patient scheduling.

Pubmed   Journal   ReadQx 

Arthritis Res Ther

A role for neutrophils in early enthesitis in spondyloarthritis.

Neutrophils with inducible IL-23 production are present in uninflamed human entheseal sites, and neutrophils are prominent in early murine spondyloarthritis-related enthesitis. We propose a role for neutrophils in the early development of enthesitis.

Pubmed   Journal   ReadQx   PMC

Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis.

ECV304 cells overexpress two of the PAD isoenzymes capable of citrullinating self-proteins. These autocitrullinated cells constitute a basic and clinical research tool that enable the detection of cit-prot-ACPAs with high diagnostic specificity and allow the identification of the specific cit-proteins targeted by individual RA sera.

Pubmed   Journal   ReadQx   PMC

Fibrotic alterations in human annulus fibrosus correlate with progression of intervertebral disc herniation.

The characterization of human AF here conducted evidence the presence of fibrosis in degenerated IVD, while highlighting the importance of considering the herniation progression stage, despite the patients' age, for a better understanding of the mechanisms behind AF failure and IVD herniation.

Pubmed   Journal   ReadQx   PMC

Rheumatology (Oxford)

Dysregulation of the gene signature of effector regulatory T cells in the early phase of systemic sclerosis.

RNA-seq of immune cells indicated the dysregulation of Fr. II eTregs in early SSc with increased proportion of the activated subpopulation.

Pubmed   Journal   ReadQx 

Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritis.

Renal mTORC1 activation could be a biomarker to reveal disease activity and predict clinical prognosis in LN patients.

Pubmed   Journal   ReadQx 

Utility of the breath-holding test in patients with systemic sclerosis.

BHT, a simple and less time-consuming test, shows excellent reliability and significant correlation with Borg scale, SHAQ, and pulmonary parameters. These results suggest that BHT might be a useful surrogate marker of pulmonary capacity in SSc patients.

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Rheum Dis

Cutaneous signs and mechanisms of inflammasomopathies.

The range of possible skin lesions is vast, ranging from urticarial, erysipelas-like and pustular rashes to erythematous patches, violaceous plaques and eventual necrosis and ulceration. This review provides a structured overview of the pathogenesis and the clinical picture with a focus on dermatological aspects of inflammasomopathies. Current treatment options for these conditions are also discussed.

Pubmed   Journal   ReadQx 

Hydroxychloroquine and lupus flare: a good drug, but we need to do better.

Pubmed   Journal   ReadQx 

Arthritis Care Res (Hoboken)

Clinical Academic Rheumatology: Still Getting More Than You Pay For.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Ann Rheum Dis

Correspondence on 'Call for action in ANCA-associated vasculitis and lupus nephritis: promises and challenges of SGLT-2 inhibitors' by Säemann and Kronbichler.

Pubmed   Journal   ReadQx 

Correspondence on 'NCF1-339 polymorphism is associated with altered formation of neutrophil extracellular traps, high serum interferon activity and antiphospholipid syndrome in systemic lupus erythematosus' by Linge et al.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…

Ann Rheum Dis

Anti-RuvBL1/2 autoantibodies in patients with systemic sclerosis or idiopathic inflammatory myopathy and a nuclear speckled pattern.

Pubmed   Journal   ReadQx 

Attenuated response to fourth dose SARS-CoV-2 vaccination in patients with autoimmune disease: a case series.

Pubmed   Journal   ReadQx 

Managing the selection of placebo group switched to experimental treatment group in post-randomised controlled trial extension studies.

Pubmed   Journal   ReadQx 

Obinutuzumab in connective tissue diseases after former rituximab-non-response: a case series.

Pubmed   Journal   ReadQx 

Response to: Correspondence on 'Call for action in ANCA-associated vasculitis and lupus nephritis: promises and challenges of SGLT-2 inhibitors' by Säemann and Kronbichler.

Pubmed   Journal   ReadQx 

Treatment of lupus: more options after a long wait.

Pubmed   Journal   ReadQx 

Arthritis Rheumatol

Giant cell arteritis with positive temporal artery biopsy but without ultrasound halo sign.

Pubmed   Journal   ReadQx 

Rheumatology (Oxford)

Granulomatous vasculitis presenting as annular erythema in neurosarcoidosis.

Pubmed   Journal   ReadQx